Hyaluronidase to Dissolve Restylane (and Juvederm)


Here is some interesting information about Hyaluronidase. I posted some of the information below. As the number of treatments are increasing in Sweden, so are the questions about corrections. This is an alternative which is used by a few of us, still and it works well, although care should be given while using this!  Please check the link above for more information!


By Peter A. Aldea, MD – Memphis Plastic Surgeon

The nice thing about Hyaluronic Acid fillers (Restylane, Perlane and Juvederm) is that they ARE reversible by injecting Hyaluronidase into them.

Before doing so, please, make sure that all swelling subsided and that the doctor injecting you knows what he/she is doing.

Peter A Aldea, MD

Hyaluronidase Risks

You state that hyaluronidase can more rapidly break down fillers in face. Does it break down natural acids in face, too? Can it cause perminant holes or scars in face? Is it FDA approved?


Hyaluronidase can rapidly reverse the effects of hyaluronic acid fillers

By Scott Trimas, MD – Jacksonville Facial Plastic Surgeon

Hyaluronidase can rapidly reverse the effects of hyaluronic acid fillers. It is a very safe product and I have been using it for 15 years. I also use hyaluronidase for dispersing the effects of local anesthesia when I do eyelid surgery and it works very well. When used in small doses, it can quickly within 24-48 hours reverse the effect of the most common fillers such asRestylane and Juvederm. It has no visible effects itself and when the filler is gone, the net result will be a return to the pre-filler correction state. In even smaller amounts you can dissolve some of the excess filler while maintaining the correction; however, that is not always possible. I hope that information helps.

Hyaluronidase is not FDA-approved

By Ira D. Papel, MD – Baltimore Facial Plastic Surgeon

Hyaluronidase is an enzyme which accelerates the absorption of hyaluronic acidbased dermal fillers. When used in small quantities it can help to smooth bumpy areas aftercosmetic filler injection. When restricted to overfilled areas, the response can take a few days to be noticeable. It does not seem to cause any degeneration of the surrounding normal tissue when used in this manner.

It is not FDA approved for this purpose as no clinical trials have ever been conducted. This is an off label use for a drug which has been used for other purposes for decades.